activated factor v การใช้

• Thrombin activates Factor V by cleaving off the B domain.
• It cleaves fibrinogen into fibrin monomers, activates Factor V, VIII, and XIII, allowing fibrin to develop a covalently cross-linked framework that stabilizes the thrombus.
• Factors III and VI are unassigned, as thromboplastin was never identified, and actually turned out to consist of ten further factors, and accelerin was found to be activated Factor V.
• Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation ( by degradating activated factor V ).
• The thereby activated factor V ( now called FVa ) is a cofactor of the prothrombinase complex : The activated factor X ( FXa ) enzyme requires calcium and activated factor V to convert prothrombin to thrombin on the cell surface membrane.
• The thereby activated factor V ( now called FVa ) is a cofactor of the prothrombinase complex : The activated factor X ( FXa ) enzyme requires calcium and activated factor V to convert prothrombin to thrombin on the cell surface membrane.
• This is opposed to the intrinsic ( amplification ) pathway which involves both activated factor IX and factor VIII . Both pathways lead to the activation of factor X ( the common pathway ) which combines with activated factor V in the presence of calcium and phospholipid to produce thrombin ( thromboplastin activity ).